Oncotarget: LncRNAs Control Cancer Metastasis through Several Signaling Pathways

Cancer is a dominant and common disease that claims the lives of many people in the world. Metastasis is a type of cancer that is characterized by malignancy. Metastasis is the combination of the early invasion and late colonization of cancer cells. Learn more about Oncotarget at Research Gate. Typically, cancer cells experience morphological transformation and change their cell-cell matrix connection to pass through the first stage of the multistep process of metastasis. The epithelial-mesenchymal transition (EMT) is a critical stage in the early events of tumor cell metastatic supply by supporting the cells with more invasive, motile potential. On the other side, Mesenchymal-epithelial transition (MET) is needed to move the cells to extravasated from the vessels into their tissue to create micrometastases. The micrometastases will eventually develop a secondary tumor after the cells survive anoikis process. Check Oncotarget journal at scimagojr.com

Long-coding RNAs (LncRNAs) are categories of transcripts that contain limited protein-coding potential and are longer than 200 nucleotides. A lot of efforts have been spent on attaining protein-coding genes to regulate cancer metastasis. Many Oncotarget articles provide limited information about the functions of LncRNAs metastasis. Several current research illustrates deregulations of LncRNAs in the different type of cancer. There is the absurd manifestation of LncRNAs in all stages of cancer development ranging from cancer initiation to progression and metastasis.

A class of EMT –inducing transcript factors such as snail, slug and ZEB1/2 are animated during EMT. Signals that grow from the tumor stroma including transforming growth factor, platelet-derived growth factor, fibroblast growth factor and insulin growth factor that is used to target EMT in cancer cells. All of these induce factors trig EMT via a complex signaling interaction involving several receptor tyrosine kinases ( RTKs) and the NOTCH, MAPK/ERK, HEDGEHOG AND PI3/Akt signaling pathways. LncRNAs have emerged as versatile control of the EMT related channels.

These findings are incredibly important to the further development of cancer treatments and protocols. By understanding growth factors in addition to other related channels, it may be possible to improve the way that cancer is addressed and understood at a molecular level. Oncotarget promotes research in these areas and spreads important findings within the global scientific community.

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